Will Ferrell

Ron Burgundy

Christina Applegate

Veronica Corningstone

Paul Rudd

Brian Fantana

Steve Carell

Brick Tamland

David Koechner

Champ Kind

Fred Willard

Ed Harken

Chris Parnell

Garth Holliday

Kathryn Hahn

Helen

Fred Armisen

Tino

Seth Rogen

Eager Cameraman

Paul F. Tompkins

MC

Danny Trejo

Bartender

Scot Robinson

Waiter at Tino's

Ian Roberts

Stage Manager

Darcy Donavan

Hot Blonde

Renee Weldon

Petite Brunette

Jerry Minor

Tino's Bassist

Holmes Osborne

Director

Charles Walker

Security Guard

Thomas E. Mastrolia

Biker Guy

Jay Johnston

Eyewitness News Member

Peter A. Hulne

Man in Kitchen

Laura Kightlinger

Donna

Adam McKay

Custodian

Joseph T. Mastrolia

Custodian

Judd Apatow

News Station Employee

Debra McGuire

News Station Employee

Kent Shocknek

Network Reporter

Monique McIntyre

Yelling Woman

Bob Rummler

Bum

Chuck Poynter

Announcer

Esmerelda McQuillan

Middle Class Mother

Angela Grillo

Elderly Woman

Lionel Allen

Wealthy Family Father

Trina D. Johnson

Wealthy Family Mother

Fred Dresch

Doctor

Glen Hambly

Middle Class Dad

Stuart Gold

Nursing Room Resident

Bill Kurtis

Bill Lawson - Narrator (voice)

Jack Black

Motorcyclist

Ben Stiller

Arturo Mendes

Luke Wilson

Frank Vitchard

Frank Gorgie

Frank the Bartender (uncredited)

Missi Pyle

Zoo Keeper (uncredited)

Tim Robbins

Public TV News Anchor (uncredited)

Vince Vaughn

Wes Mantooth (uncredited)

Jerry Stiller

Man in Bar (uncredited)

Holly Traister

Secretary (uncredited)

Matthew Vlahakis

Zoologist with Panda in Doug or Glen scene (uncredited)

Richard Yett

Reporter / Anchor (uncredited)