Claudette Colbert

Cleopatra

Warren William

Julius Caesar

Henry Wilcoxon

Marc Antony

Joseph Schildkraut

King Herod

Ian Keith

Octavian

Gertrude Michael

Calpurnia

C. Aubrey Smith

Enobarbus

Irving Pichel

Apollodorus

Arthur Hohl

Brutus

Edwin Maxwell

Casca

Ian Maclaren

Cassius

Eleanor Phelps

Charmion

Leonard Mudie

Pothinos

Grace Durkin

Iras

Ferdinand Gottschalk

Glabrio (scenes deleted)

Claudia Dell

Octavia

Harry Beresford

Soothsayer

Jayne Regan

Lady Vesta

William Farnum

Lepidus

Lionel Belmore

Fidius

Florence Roberts

Lady Flora

Richard Alexander

General Philodemas

Celia Ryland

Lady Leda

William V. Mong

Court Physician

Robert Warwick

General Achillas

George Walsh

Courier

Kenneth Gibson

Scribe

Wedgwood Nowell

Scribe

Bruce Warren

Scribe

Robert Seiter

Aelius (as Robert Manning)

Edgar Dearing

Convict

John Carradine

Roman Citizen/Party Guest/Soldier (uncredited) (voice)

Wilfred Lucas

Roman Greeting Antony (uncredited)

David Niven

Slave (uncredited)

Olga Celeste

Slave Girl (uncredited)