Ed Helms

Hogan 'Hoagie' Malloy

Jon Hamm

Bob Callahan

Jeremy Renner

Jerry Pierce

Jake Johnson

Randy 'Chilli' Cilliano

Hannibal Buress

Kevin Sable

Annabelle Wallis

Rebecca Crosby

Isla Fisher

Anna Malloy

Rashida Jones

Cheryl Deakins

Leslie Bibb

Susan Rollins

Maxwell Ross

Teen Jerry

Brayden Benson

Young Jerry

Jaren Lewison

Teen Hoagie

Braxton Bjerken

Young Hoagie

Kevin Tyler Moody

Teen Randy

Tyler Crumley

Young Randy

Elijah Marcano

Teen Bob

Braxton Alexander

Young Bob

Xavion Shelton

Teen Kevin

Legend Williams

Young Kevin

Kella Raines

Teen Cheryl

Th'Yana Star

Young Cheryl

Steve Berg

Louis

Nora Dunn

Linda Malloy

Brian Dennehy

Mr. Cilliano

Thomas Middleditch

Dave

Lil Rel Howery

Reggie

Sebastian Maniscalco

Pastor

Indiana Sifuentes

Mexican Jerry

Trayce Malachi

Young Boy in Mall

Jock McKissic

Marvin

Al Mitchell

AA Member

Kate Kneeland

Wedding Caterer

Vince Pisani

Wedding Planner

Kurt Yue

Doctor Yuen

Jim Esposito

Martin - Neighbor

Loren Lott

Sable's Girlfriend

Andrew Tran

Boy Attacker

Carrie Brownstein

Therapist (uncredited)

Courtney Brown

Nurse (uncredited)

Melissa LeEllen

Mall Patron (uncredited)

Donald K. Overstreet

Bar Patron (uncredited)

Grace Pippas

Student (uncredited)

Tatum Price

First Class Passenger (uncredited)

Leslie Sides

Freedom Atlantic Employee (uncredited)

Joey Thurmond

Wedding Guest (uncredited)