William Bendix

George Herman 'Babe' Ruth

Claire Trevor

Claire Hodgson Ruth

Charles Bickford

Brother Matthias

Sam Levene

Phil Conrad

William Frawley

Jack Dunn

Gertrude Niesen

Nightclub Singer

Fred Lightner

Miller Huggins

Stanley Clements

Western Union Boy

Robert Ellis

Babe Ruth as a Boy (as Bobby Ellis)

Lloyd Gough

Gambler Dalton

Matt Briggs

Colonel Jacob Ruppert

Paul Cavanagh

Dr. Menzies

Warren Douglas

Boston Braves' Rookie

Pat Flaherty

Bill Carrigan, Red Sox Manager

Mark Koenig

Mark Koenig

Richard Lane

Boston Braves' coach

Ziggy Sears

Umpire Ziggy Sears

Bucky Harris

Bucky Harris - Baseball Player

Harry Wismer

Harry Wismer - Sports Announcer

Mel Allen

Mel Allen - New York Yankees Radio Announcer

H.V. Kaltenborn

H. V. Kaltenborn - Radio News Commentator

Knox Manning

Narrator

Al Bain

Barfly (uncredited)

Oliver Crawford

Reporter (uncredited)