Ron Fazio

The Toxic Avenger / Apocalypse Inc. Executive

John Altamura

The Toxic Avenger

Phoebe Legere

Claire

Rick Collins

Apocalypse Inc. Chairman

Rikiya Yasuoka

Big Mac

Tsutomu Sekine

Announcer

Mayako Katsuragi

Masami

Shinoburyû

Shockikuyama

Lisa Gaye

Malfaire

Jessica Dublin

Mrs. Junko

Jack Cooper

Mr. Junko

Erika Schickel

Psychiatrist

Karen King

Bad Girl

Melissa Osborne

Bad Girl

Helen Wheels

Bad Girl

Bonnie Garvin

Bad Girl

Michael Jai White

Apocalypse Inc. Executive

Joe Fleishaker

Apocalypse Inc. Executive

William Decker

Apocalypse Inc. Executive

Dan Snow

Cigarface

Andrew Wolk

Pus Man

Eric Alan

Homeless Couple

William E. Benson

Father O'Reilly

Elliot Weiss

Dog Face

Arthur M. Jolly

Blind Choir Singer

Charlotte Kaufman

Blind Baby

Lily Hayes Kaufman

Toxic Child

Lisbeth Kaufman

Toxic Child

Patricia Kaufman

Diaper Changer

Jeffrey W. Sass

Good Person of Tromaville

Harry Williams Jr.

Good Person of Tromaville

David Greenspan

Good Person of Tromaville

Kei Nakata

Sumo Wrestler

Lloyd Kaufman

Sumo Wrestler / Fish Salesman (voice)

Go Nagai

Tsukudani Expert

Paul Borghese

Lou Sipher (uncredited)

Scott Leva

The Dark Rider (uncredited)

Ziko Uchiyama

Person at Odaiba Beach