Frank Welker

Fred Jones / Scooby-Doo (voice)

Casey Kasem

Shaggy Rogers (voice)

Heather North

Daphne Blake (voice)

Nicole Jaffe

Velma Dinkley (voice)

Candi Milo

Charlene Otero / Museum Guide / Old Woman #1 (voice)

Maria Canals-Barrera

Sofia Otero / Old Woman #2 (voice)

Jesse Borrego

Luis Otero / Musician #2 / Suspicious Tourist (voice)

Brandon Gonzales

Jorge Otero (voice)

Castulo Guerra

Señor Fuente / Man #1 (voice)

Benito Martinez

El Curandero / Man #2 (voice)

Darlene Mendoza

Natalia Otero / Little Girl (voice)

Rita Moreno

Doña Dolores / Woman #3 (voice)

Allyse Rivera

Carolina Otero (voice)

Casey Sandino

Sebastian Otero / Little Boy (voice)

Eddie Santiago

Alejo Otero / Musician #1 (voice)

Rip Taylor

Mr. Smiley / Ghost of Señor Otero (voice)

Michael Forest

El Chuprecabra (voice)